PDE5 Inhibitor drugs - Benefit and side effects of PDE5 Inhibitor drugs

The PDE-5 inhibitors sildenafil (Viagra) vardenafil (Levitra) and tadalafil (Cialis) have been taken by tens of millions of men as an erectile dysfunction treatment. There have been dozens of cases of nonarteritic anterior ischemic optic neuropathy (NAION) described in patients using PDE5 Inhibitor drugs. NAION is a common optic neuropathy in patients in the age group using these drugs and the question arises whether or not PDE-5 inhibitors are causing NAION. There is some evidence to support PDE-5 inhibitors as a cause of NAION. PDE-5 inhibitors probably are a cause of a common ischemic disorder of the optic disc. PDE5 Inhibitor must be avoided in men who have already experienced NAION in one eye. Patients should be warned to seek medical attention if they have visual field or acuity loss after using PDE-5 inhibitors.

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